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#1 Aug. 4, 2012 17:11:09

Harpy
From: South Coast, NSW, Australia
Registered: 2010-07-19
Posts: 173
Profile  

Vitamin D & Autoimmune Thyroid Disease

Just searching around for MS stuff and found this, seems there is a connection between Vitamin D & Thyroid disease as well,
So probably a good idea to get levels checked.
Searched quickly on site & didn't find it posted before.
Link & Quote below:

"Vitamin D and autoimmune thyroid diseases

Shaye Kivity, Nancy Agmon-Levin, Michael Zisappl, Yinon Shapira, Endre V Nagy, Katalin Dankó, Zoltan Szekanecz, Pnina Langevitz and Yehuda Shoenfeld

Abstract

The role of vitamin D as an immune modulator has been emphasized in recent years, and low levels of the hormone were observed in several autoimmune diseases including multiple sclerosis and systemic lupus erythematosus. Vitamin D mediates its effect though binding to vitamin D receptor (VDR), and activation of VDR-responsive genes. While VDR gene polymorphism was found to associate with autoimmune thyroid diseases (AITDs), few studies examined levels of vitamin D in these patients and those that did yielded conflicting results. We therefore undertook to evaluate the levels of vitamin D in patients with AITDs compared to patients with non-AITDs and healthy controls. Serum vitamin D (25-OH) levels were measured in 50 patients with AITDs, 42 patients with non-AITDs and 98 healthy subjects, utilizing the LIAISON chemiluminescence immunoassay (DiaSorin, Saluggia, Italy). Vitamin D deficiency was designated at levels lower than 10 ng/ml. Antithyroid antibodies, thyroid functions and demographic parameters were evaluated in all patients. The prevalence of vitamin D deficiency was significantly higher in patients with AITDs compared with healthy individuals (72% versus 30.6%; P<0.001), as well as in patients with Hashimoto's thyroiditis compared to patients with non-AITDs (79% versus 52%; P<0.05). Vitamin D deficiency also correlated to the presence of antithyroid antibodies (P=0.01) and abnormal thyroid function tests (P=0.059).
Significantly low levels of vitamin D were documented in patients with AITDs that were related to the presence of anti thyroid antibodies and abnormal thyroid function tests, suggesting the involvement of vitamin D in the pathogenesis of AITDs and the advisability of supplementation."


Whole study only available by log in or user pay.


I am not a Registered Medical Professional nor am I a Formal Researcher of any description, therefore everything that I say and write is purely my own opinion that is based on my own personal experience and information that I have read, henceforth anything I say or write cannot be construed as advice in any shape or form.
Every individual needs to do their own research so that they can make fully informed decisions about their own future and take full responsibility for the decisions they make.
My partner is the GD patient, I am just her researcher and advocate.
PTU treatment for Graves 7+ years ongoing, Supported by Low Allergenic Paleo Diet, Supplements, Yoga, Meditation, Exercise and Lifestyle changes.
Tests in Jan, March, June, Sept and Dec 2012, normal range for FT3, FT4 and TSH and receptor antibodies only marginally above normal in March, well in range in Dec - Scaling down PTU dose and looking forward to a remission attempt in the near future.

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#2 Aug. 4, 2012 20:53:18

Carito71
Registered: 2012-06-25
Posts: 319
Profile  

Vitamin D & Autoimmune Thyroid Disease

Very interesting. I think I had heard something about it before. A friend of my husbands was told 2 weeks ago that he was hypo and was given T3 and T4 plus he was also told he was needing vit. D. Probably related??? This friend also has Celiac like me. Thank you for the information.


~ Fellow GD patient diagnosed June 2012 with a non-existent TSH, elevated fT3 and fT4, and a TSI of 4.5. On Methimazole 30mg/day for the first 8 weeks. On Methimazole 10mg/day for the next 6 weeks. On Methimazole 5mg/day for a week and a half. On Methimazole 5mg every 4 days for a month. On Methimazole 2.5mg/day starting Nov 15. Current labs show a normal fT4, a normal TSH, and a TSI of 3.2. Diet: Gluten and yeast free. Love to read and learn. Very interested in the immune part of GD ~

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#3 Aug. 5, 2012 05:53:09

paleblue
Registered: 2011-01-29
Posts: 18
Profile  

Vitamin D & Autoimmune Thyroid Disease

When I first got GD, my vitamin D levels were fine, but recently my levels were low, which was a total surprise. I started taking liquid D, and am now w/out meds. I always wonder though–does the vitamin D deficiency contribute to gettting GD, or is there something about GD that inhibits absorption of D? Does the article make any distinction? Thanks!

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#4 Aug. 5, 2012 17:06:12

Harpy
From: South Coast, NSW, Australia
Registered: 2010-07-19
Posts: 173
Profile  

Vitamin D & Autoimmune Thyroid Disease

There is a strong corrolation between Vitamin D deficiency and many Autoimmune diseases & cancers, but that is not to say that it is a causal relationship, just that very often both conditions are present at the same time.
Vitamin D is a modulator of the adaptive immune response by stimulation of Regulatory T-Cells, so there is the possibility that low Vit D levels may leave the door open for an autoimmune response, but low Vit D levels will certainly be an aggravating factor when there is an autoimmune disease present.
So the main thing is, knowing that there is a risk of low Vit D levels when GD is present, to get levels checked and consult with a practitioner to normalize levels by supplementation and/or direct sun exposure.
Note Vitamin D is produced in the skin by exposure to UVB rays which are strongest in the middle of the day (10-2), they are also the ones that are responsible for the sunburn response, which appears to be an indicator that you have maxed out on Vitamin D, conversly the UVA rays are the ones that penetrate much deeper, produce the tanning effect (melanin production) and cause the greater skin damage. Most guidelines say 15-20 min of daily good body exposure to the sun is plenty, so don't get burned, this can produce 20-30,000 IU of Vitamin D. Obviously do not apply sunscreen for this brief time and also do not have a shower immediately after as the Vit D is close to the surface and needs time to be absorbed by the body.


I am not a Registered Medical Professional nor am I a Formal Researcher of any description, therefore everything that I say and write is purely my own opinion that is based on my own personal experience and information that I have read, henceforth anything I say or write cannot be construed as advice in any shape or form.
Every individual needs to do their own research so that they can make fully informed decisions about their own future and take full responsibility for the decisions they make.
My partner is the GD patient, I am just her researcher and advocate.
PTU treatment for Graves 7+ years ongoing, Supported by Low Allergenic Paleo Diet, Supplements, Yoga, Meditation, Exercise and Lifestyle changes.
Tests in Jan, March, June, Sept and Dec 2012, normal range for FT3, FT4 and TSH and receptor antibodies only marginally above normal in March, well in range in Dec - Scaling down PTU dose and looking forward to a remission attempt in the near future.

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#5 Aug. 5, 2012 17:40:12

paleblue
Registered: 2011-01-29
Posts: 18
Profile  

Vitamin D & Autoimmune Thyroid Disease

Thanks Harpy!

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#6 Aug. 5, 2012 18:51:58

mvk
Registered: 2012-04-03
Posts: 31
Profile  

Vitamin D & Autoimmune Thyroid Disease

Hi,

I think Kimberly made a reference recently about Vitamin D levels in a study she referred to and I tried to search for it but can't find it of course. If someone remembers when and where to find this information would you please post it for me. I think I should be asking to get a Vitamin D level drawn and want to be prepared when I see my endo the next time. Thank you so much for the help!

mvk

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#7 Aug. 5, 2012 20:23:10

klm
Registered: 2012-08-05
Posts: 1
Profile  

Vitamin D & Autoimmune Thyroid Disease

I am waiting for my 1st appt with my endocrinolgist next week. According to all my test results my doctor is pretty sure it's Graves Disease. So glad that I have found a place where others have gone thru the same sypmtoms and it's not in my head. The last few months have been rough with extreme fatigue, intolerance to heat, multiple other symtoms and to mix it up a little, vertigo. Which they think is related to sinus issues. I also did find out that I have severe vitamin d deficiancy, a level of 12.6. I have been put on Drysdol once a week for 8 weeks. It has helped get back a little bit of energy, just not back to normal.

Edited Kimberly (Aug. 6, 2012 11:26:50)

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#8 Aug. 6, 2012 11:01:47

Darcy43
From: Michigan
Registered: 2012-04-09
Posts: 125
Profile  

Vitamin D & Autoimmune Thyroid Disease

This is absolutely true.

Two years ago when I had bruising and extreme hair loss my OB/GYN ran a test and I was Vitamin D3 deficient, extremely…If only I had known to have my thyroid check..it would have saved me another year of the same symptoms (with a goiter and sore throat). That was my whisper that you are leaning towards hyPER and do something…again I had no idea. A year later, I am diagnosed with Graves…

Yes I believe it is an indicater. Bone loss/muscle wasting, etc. are symptoms and the V D3 deficiency is a good indicating that something may not be right. I was told I wasn't getting enough sun (which is the only way to really get V-D3 (not from dairy). I thought this to be correct because while I lived in Florida I never had a deficiency. I moved up north, lack of sun and bingo.

Thanks for the information.

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#9 Aug. 6, 2012 11:30:43

Kimberly
Online Facilitator
From: Phoenix, AZ
Registered: 2008-10-14
Posts: 2708
Profile  

Vitamin D & Autoimmune Thyroid Disease

Just a quick note to stress the importance of working with your doctor to get tested prior to adding a Vitamin D supplement. My own endo does this testing and has recommended supplementation in my case, but there can be toxic effects if you get *too* much Vitamin D (as is the case with most other vitamins/minerals).

@klm - Hello and welcome! Please note that your post was approved with the link removed. We do allow the posting of links here, but they need to come specifically from medical journals or medical organizations. (You can read more in the “New User? Read This First!” thread in the announcements section of the forum.)


Kimberly
GDATF Forum Facilitator

…through nature's inflexible grace, I'm learning to live…
– Dream Theater

Edited Kimberly (Aug. 6, 2012 11:31:58)

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#10 Aug. 25, 2012 21:52:08

jlnay
Registered: 2010-07-03
Posts: 4
Profile  

Vitamin D & Autoimmune Thyroid Disease

Had my Vitamin D tested a year ago and my level was extremely low. I have been on 3000 Vitamin D daily for about a year now and feel so much better and my levels are in the normal range. My doctor said I will probably have to take the supplement for the rest of my life.

Get your levels checked you will feel better

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