Yes, I had liver problems with methimazole- I was on 5 mg. daily for 7 weeks. When I had my thyroid levels tested (which ended up being normal after treatment), my liver enzymes were 8 times the normal amount. I had a baseline before taking methimazole, and they were in range then. I was told to stop taking methimazole right away. My liver enzymes were tested 3 days later to make sure they were coming down (which they were). I had them tested again about a month later and they were normal. My dr. also ordered an abdominal ultrasound to make sure everything was okay. Fortunately, everything is fine.
I managed to stay euthyroid for 6 weeks and had my surgery to remove all of my thyroid 8 weeks ago. I am on Synthroid now and doing pretty well. My TSH came down from 6.35 (6 weeks post surgery) to .79 just last week after 1 dose adjustment. My free T4 is in the upper range of normal and I feel pretty good for the most part. I get some headaches, but I think that may be due to life with 4 little boys and homeschooling the older 3 and the youngest being 9 months old! I am grateful I was able to get a thyroidectomy bc I will never have to experience being hyper again. It depends on the person what treatment plan is the best. I tried methimazole and it just didn't work for me bc of the liver issues. I can honestly say I feel better in many ways euthyroid after surgery than I did on methimazole, but then again, maybe the liver enzymes contributed to the off feeling while I was on the meds.
I didn't have any symptoms of elevated enzymes like fever, sore throat, yellow skin, dark urine. It was just discovered on a liver panel. I asked for the lab as I am very sensitive to medicine. Glad I asked! My TSH dropping from 6.35 to .79 in 2 weeks with just a 12 mcg. change in dosing of Synthroid shows that too. I have some medicine allergies too, so if you are sensitive to medication in general and even if not, I would ask for the liver panel when you start ATD's. Good luck!
Homeschooling mom to 4 wonderful boys!
Diagnosed with Graves Disease after my 4th baby- March 2012
Started on 5 mg. of methimazole daily for 7 weeks
Euthyroid at the end of those 7 weeks, but had to stop methimazole as liver enzymes were 8 times normal range.
Total Thyroidectomy- 6/15/12
Started Synthroid (brand name) 100 mcg. 2nd day after surgery for 6 weeks (TSH: 6.35 & free T4 in upper range and T3 just under mid- range).
Upped Synthroid to 112 mcg. 7/27/12
Euthyroid as of 8/10/12 on 112 mcg. Synthroid (TSH .79 and free T4 in upper range).
Edited adenure (Aug. 20, 2012 15:42:26)