Hello - TPOab (Thyroid Peroxidase Antibodies) are directed against TPO, an enzyme that is involved in thyroid hormone synthesis. The presence of TPOab is considered a potential marker for autoimmune thyroid disease (Graves' or Hashimoto's thyroiditis), but is not specifically diagnostic for Graves’ disease. Some people actually have elevated TPOabs with completely normal thyroid function, although this situation is usually watched closely to see if thyroid issues do eventually develop.
The key antibody tests for Graves' are TRAb (Thyrotropin Receptor Antibody) or TSI (thyroid stimulating immunoglobulin).
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Edited Kimberly (Sept. 21, 2012 10:16:07)