I was diagnosed with Graves' in 2002. At the time radioactive treatment was the norm, at least in AZ. Because I had both the associated eye and skin disease I wanted to try to control the disease with meds in the hopes that these conditions would improve over time.
Fortunately I was working with an endocrinologist at the time who was willing to let me try what was then called the European protocol–methiamazole to shut down the thyroid gland and Synthroid to replace the thyroid hormone (early on I had to take a beta blocker as well to reduce my heart rate). It took 12 years for my TRAB to register negative–eg. no anti thyroid antibodies. For most of this period I felt completely normal and symptoms of both the eye and skin diseases disappeared.
In 2014 I went off all of the meds. My bloodwork has been fine until 6/29/20 when my total blood cholesterol increased from 161 on 2/20/20 to 213 on 6/29/20, despite the fact that I am on a statin and have made no changes to diet and exercise, and my TSH increased from 1.32 to 2.70 (for the 6 years since remission it has fluctuated from 1.02-1.32). Additionally I've developed symptoms such as extreme fatigue, sleeping 10 hours a day, and muscle weakness in the thigh muscles.
At the time I went into remission in 2014 my endocrinologist, now retired, warned me that I would not stay in remission forever. He said flatly that I would either develop active Graves' or Hashimotos.
I just read the wonderful article on this site about subclinical hypothyroidism which seems like what I have. In my case the fatigue, cardiovascular disease and lipid abnormalities seem to make levothyroxine treatment a reasonable choice as I have no signs of osteoporosis and exercise daily. The problem is my endocrinologist retired and I was set to see a new one before Covid-19 hit but she has cancelled all appointments.
Any input would be greatly appreciated.